

The French only owned the ground for three years before they sold it to the U.S. The Spanish controlled the area of Southeast Missouri until 1800 when they ceded or gave away the land to France (Spain lost a war with France and giving them the land West of the Mississippi River was part of the treaty). In 1794, Francois Lesieur moved south of New Madrid a ways and started the community of Little Prairie, now known as Caruthersville. The first permanent settlement in Southeast Missouri was created by Peter LaForge at New Madrid in 1787, as a trading post with Delaware and Shawnee Indians that had moved west from their original homes in the East.

Genevieve, Cape Girardeau, and New Madrid. Under Spanish rule, the land west of the Mississippi River was divided into five districts: St. After the French lost the French and Indian War in 1763, it gave all of the land EAST of the Mississippi River to England, and all of the land WEST of the Mississippi River to Spain (an ally to England). Under French control the only permanent settlement in Southeast Missouri was at the town of Ste. He called the new land, Louisiana, named after the French King Louis the XIV (14th). In 1682, French explorer La Salle, traveled down the Mississippi River and claimed all of the land on the west and east side of Mississippi River for France. In 1673, French explorers Jacques Marquette and Louis Joilet were the first European explorers to lay eyes on southeast Missouri as they traveled down the Mississippi River. The Spanish explorer Hernando De Soto was the first European explorer to venture anywhere near Southeast Missouri, although there is no evidence that he did not go further north of Memphis, he was only the first of several that would later venture into southeast Missouri.
